A Systematic Review on the Effectiveness of Different Functional Treatments for Acute Ankle Sprains

Background: An ankle sprain is a very common sport-related injury and can reduce participation in sports and employment. It can also create further complications in the function of the joint. Purpose: To evaluate the effectiveness of different functional treatments and to ascertain which functional treatment is the most effective method for acute ankle sprains. Study Design: Systematic review. Methods: The design of this systematic review was developed in accordance with PRISMA-P 2015 statement and performed according to its guidelines. A computerized literature search was performed from PubMed Central, MEDLINE via OVID and Cochrane library. Randomized controlled trials or quasi-experimental studies, published within a ten-year period (2007 to 2017), in peer-reviewed journals, with full-text articles and written in English were included in this study. Any type of functional treatments being applied to treat acute ankle sprains were considered as an intervention and only adult participants were included in this review. Surgical methods, unpublished trials, not written in the English language or not experimental research were excluded. Results: From the pooled data of this review, the stocking was more effective at improving pain, swelling, functional outcomes, range of motion, and return to sport/work, and had higher patient satisfaction than the bandage. There was no evidence that the taping and lace-up brace were more effective than other functional interventions in the treatment of acute ankle sprains. Furthermore, the prevalence of complications was greatest for the taping and lace-up brace interventions. The semi-rigid or posterior rigid support group had a better functional recovery and higher patient satisfaction, but some complications were present. Conclusion: The semi-rigid or posterior rigid support group and stocking were the most effective functional interventions for acute ankle sprain treatment. What is known about this subject: The functional treatments are becoming popular due to being effective, inexpensive and simplistic to apply. Different types of functional interventions have been used according to the choice of clinicians and patients in the treatment of ankle sprains. According to the previous researches, semi-rigid support, ankle braces, bandage and lace-up supports have greater advantages than other functional treatments from different perspectives (Example. the elastic bandage had a slower recovery rate than semi-rigid brace but less complications than taping, the lace-up support was better in swelling management than other functional treatments). What this study adds to existing knowledge: This study found that the stocking is an effective treatment for managing acute ankle sprains. It is valuable for the patient because the cost of the stocking is considerably cheaper than other functional treatments and it is very easy to wear. Some popular functional treatments like lace-up support; taping and semi-rigid braces were shown to have some complications

Bcl9の異なるエピトープを認識する二つの抗体を用いた免疫組織化学的マッピングによるミャンマー国若年性発症肝細胞がんの特徴付け

B-cell lymphoma 9 (Bcl9) is the core component of Wnt/β-catenin signaling and overexpressed in nuclei of various tumors, including hepatocellular carcinoma (HCC). However, the extent of Bcl9 expression relative to HCC differentiation stage and its functional aspects are poorly understood. In this study, we examined the expression pattern of Bcl9 immunohistochemically, using two anti-Bcl9 antibodies; one was a conventional polyclonal-antibody (anti-Bcl9ABC) against amino acid no.800?900 of human-Bcl9, while the other (anti-Bcl9BIO) was against amino acid no.50?200, covering Pygopus-binding sites of Bcl9. Immunohistochemistry using anti-Bcl9BIO demonstrated distinctive staining in the cytoplasm, while the anti-Bcl9ABC signal was detected in both cytoplasm and nuclei of HCC cells, reflecting different states of Bcl9 function because Pygopus-binding to Bcl9 is essential to exert its function together with β-catenin in nucleus. Quantitative analysis revealed a significantly higher immunohistochemical-score by anti-Bcl9BIO in normal liver comparing various differentiation grades of HCC (P < 0.004), whereas no significant difference was noted with anti-Bcl9ABC. Interestingly, immunohistochemical-score of anti-Bcl9BIO in patients aged < 40 years was significantly lower than that of ? 40 years group (P < 0.01). The results indicated that anti-Bcl9BIO detected cytoplasmic Bcl9, which does not bind to Pygopus suggesting it could be a useful indicator for development of HCC in young Myanmar patients.長崎大学学位論文 学位記番号:博(医歯薬)甲第1129号 学位授与年月日:平成31年3月20日Author: Myat Thu Soe, Yasuaki Shibata, Myo Win Htun, Kuniko Abe, Kyaw Soe, Nay Win Than, Thann Lwin, Myat Phone Kyaw and Takehiko KojiCitation: Acta Histochemica et Cytochemica, 52(1), pp.9-17; 2019Nagasaki University (長崎大学)課程博

Enhancements of minimax access-point setup optimisation approach for IEEE 802.11 WLAN

As a flexible and cost-efficient internet access network, the IEEE 802.11 wireless local-area network (WLAN) has been broadly deployed around the world. Previously, to improve the IEEE 802.11n WLAN performance, we proposed the four-step minimax access-point (AP) setup optimisation approach: 1) link throughputs between the AP and hosts in the network field are measured manually; 2) the throughput estimation model is tuned using the measurement results; 3) the bottleneck host suffering the least throughput is estimated using this model; 4) the AP setup is optimised to maximise the throughput of the bottleneck host. Unfortunately, this approach has drawbacks: 1) a lot of manual throughput measurements are necessary to tune the model; 2) the shift of the AP location is not considered; 3) IEEE 802.11ac devices at 5 GHz are not evaluated, although they can offer faster transmissions. In this paper, we present the three enhancements: 1) the number of measurement points is reduced while keeping the model accuracy; 2) the coordinate of the AP setup is newly adopted as the optimisation parameter; 3) the AP device with IEEE 802.11ac at 5 GHz is considered with slight modifications. The effectiveness is confirmed by extensive experiments in three network fields

A Channel Assignment Extension of Active Access-Point Configuration Algorithm for Elastic WLAN System and Its Implementation Using Raspberry Pi

Recently, Wireless Local-Area Network (WLAN) has become prevailing as it provides flexible Internet access to users with low cost through installation of several types of access points (APs) in the network. Previously, we proposed the active AP configuration algorithm for the elastic WLAN system using heterogeneous APs, which dynamically optimizes the configuration by activating or deactivating APs based on traffic demands. However, this algorithm assumes that any active AP may use a different channel from the other ones to avoid interferences, although the number of non-interfered channels in IEEE 802.11 protocols is limited. In this paper, we propose the extension of the AP configuration algorithm to consider the channel assignment to the active APs under this limitation. Besides, AP associations of the hosts are modified to improve the network performance by averaging loads among channels. The effectiveness of our proposal is evaluated using the WIMNET simulator in two topologies. Finally, the elastic WLAN system including this proposal is implemented using Raspberry Pi for the AP. The feasibility and performance of the implementation are verified through experiments using the testbed

A Minimax Approach for Access Point Setup Optimization in IEEE 802.11n Wireless Networks

Recently, an IEEE 802.11n access point (AP) prevailed over the wireless local area network (WLAN) due to the high-speed data transmission using the multiple input multiple output (MIMO) technology. Unfortunately, the signal propagation from the 802.11n AP is not uniform in the circumferential and height directions because of the multiple antennas for MIMO. As a result, the data transmission speed between the AP and a host could be significantly affected by their relative setup conditions. In this paper, we propose a minimax approach for optimizing the 802.11n AP setup condition in terms of the angles and the height in an indoor environment using throughput measurements. First, we detect a bottleneck host that receives the weakest signal from the AP in the field using the throughput estimation model. To explore optimal values of parameters for this model, we adopt the versatile parameter optimization tool. Then, we optimize the AP setup by changing the angles and the height while measuring throughput. For evaluations, we verify the accuracy of the model using measurement results and confirm the throughput improvements for hosts in the field by our approach

Low Incidence of Renal Dysfunction among HIV-Infected Patients on a Tenofovir-Based First Line Antiretroviral Treatment Regimen in Myanmar.

BACKGROUND: Since 2004, Médecins Sans Frontières-Switzerland has provided treatment and care for people living with HIV in Dawei, Myanmar. Renal function is routinely monitored in patients on tenofovir (TDF)-based antiretroviral treatment (ART), and this provides an opportunity to measure incidence and risk factors for renal dysfunction. METHODS: We used routinely collected program data on all patients aged ≥15 years starting first-line TDF-based ART between January 2012 and December 2013. Creatinine clearance (CrCl) was assessed at base line and six-monthly, with renal dysfunction defined as CrCl < 50 ml/min/1.73 m2. We calculated incidence of renal dysfunction and used Cox regression analysis to identify associated risk factors. RESULTS: There were 1391 patients, of whom 1372 had normal renal function at baseline. Of these, 86 (6.3%) developed renal dysfunction during a median time of follow-up 1.14 years with an incidence rate of 5.4 per 100 person-years: 78 had CrCl between 30-50 ml/min/1.73 m2 and were maintained on TDF-based ART, but 5 were changed to another regimen: 4 because of CrCl <30 ml/min/1.73 m2. Risk factors for renal dysfunction included age ≥45 years, diagnosed diabetes, underlying renal disease, underweight and CD4 count <200 cells/mm3. There were 19 patients with baseline renal dysfunction and all continued on TDF-based ART: CrCl stayed between 30-49 ml/min/1.73 m2 in five patients while the remainder regained normal renal function. CONCLUSIONS: In a resource-poor country like Myanmar, the low incidence of renal toxicity in our patient cohort suggests that routine assessment of CrCl may not be needed and could be targeted to high risk groups if resources permit

Design and Implementation of Solar inverter for Pure Sine Wave Inverter

Abstract: The dc-ac converter is a circuit that convert the dc voltage supply to ac voltage output and this converter also known as inverter. Inverter is used in many types at industrial and commercial applications especially in dc-ac conversion ac motor derives system controls and uninterruptible power supply. This thesis combined the knowledge at electrical. The main test of this paper is to construct a pure sine wave inverter system .The developed system used common electronic parts such as operational amplifier gate driver dc to dc converter and power MOSFETS .The MOSFET also use controller by gate driver circuits .This thesis is started with system design of inverter circuit by using the paper calculation to get the waveform of output and switching of MOSFETS .The hardware circuit is then constructed and the output waveform are shown by oscilloscope. This paper will include operation, analysis control strategy and experiment result based on the design calculation and hardware implementation